it is basically the webapp but wrapped in an app container, the one exception is that the desktop app includes what was formerly known as the Floating Bar, which is now called the Miniboard and resides under the overflow menu 'More', a feature I use a lot to readback whatever text I've selected with my cursor in whatever app avoiding the need to cut and paste or download and upload.

With Natural Reader 16, the desktop app is finally on par with the webapp.

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Free text to speech for mac os 10.6